![]() In the continuation phase, there were no differences in acute psychiatric care use between medications. 0001 vs paroxetine, sertraline, and topiramate). Those taking venlafaxine were significantly more likely to achieve remission (P =. In the acute phase, patients improved by a mean of 6.8-10.1 points on the PCL-5 and 0.0%-10.9% achieved remission of PTSD symptoms. Twelve-week acute-phase changes in PCL-5 score and remission of PTSD symptoms were compared among patients receiving the different medications, as was use of acute psychiatric services in the subsequent 6-month continuation phase. The current study addresses several weaknesses in that study, including limited standardization of treatment duration, inability to account for prior treatment receipt, use of an outdated symptomatic assessment for PTSD, and lack of functional outcome.Ī total of 834 VA outpatients were identified with DSM-5 clinical diagnoses of PTSD between October 2016 and March 2018 who initiated one of the medications and met prespecified criteria for treatment duration and dose, combined with baseline and endpoint DSM-5 PTSD Checklist (PCL-5) measurements. One prior study using US Department of Veterans Affairs (VA) medical records data to compare these agents found no differences in symptom reduction in clinical practice. 11 Office of Systems Redesign and Improvement, Washington, DC, USA.įluoxetine, paroxetine, sertraline, topiramate, and venlafaxine have previously shown efficacy for posttraumatic stress disorder (PTSD).10 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.9 National Center for Patient Safety, White River Junction, Vermont, USA.8 Clinical Epidemiology Program, Veterans Affairs Medical Center, White River Junction, Vermont, USA.7 Department of Community & Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.6 Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.5 The Dartmouth Institute for Health Policy & Clinical Practice, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.4 Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.3 Veterans Affairs Medical Center, White River Junction, Vermont, USA.2 National Center for PTSD, White River Junction, Vermont, USA. ![]() 1 Brian Shiner, MD, MPH VA Medical Center 215 North Main St, 116D White River Junction, VT 05009.
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